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Even in ancient times people are unaware with the existence of living organisms invisible for the eye, causing illness. As a result, the ancient Greek scientist and physician Hippocrates expressed this assumption in one of his operates. But come to grips with their study of mankind has been in a position only just after the Dutch optician van Leeuwenhoek within the XVI century developed the first microscope and saw firsthand the bacteria inside a drop of water. Then again, quite a few in the class scientist denied the existence of pathogens essaystone within a handful of centuries just after the invention of Leeuwenhoek.

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